TMAJ
http://tmaj.pathology.jhmi.edu
TMAJ is open-source software designed to support information and images related to tissue micro-arrays. It contains support for multiple organ systems, multiple users, image analysis, and is designed to be compliant with HIPPA regulations. Frida was added to TMAJ, and thus TMAJ now supports image analysis.
Frida
http://bui2.win.ad.jhu.edu/frida/
Frida is image analysis software. Frida was developed by the Johns Hopkins University Tissue Microarray Core Facility. Frida is open source and written in 100% Java. Frida makes use of functionality from the NIH's ImageJ application. Note that Frida was recently added to TMAJ, and you should use TMAJ to get the latest functionality from Frida. This version of Frida was discontinued and the current development focus is on TMAJ.
Color Deconvolution for TMA images
http://colordecontmas.sourceforge.net/
This is a collection of ImageJ macros (scripts) for performing color deconvolution and analysis of immunohistochemistry (IHC) staining on tissue microarray (TMA) images